Orbiting gas station could refuel lunar missions – space – 31 July 2009 – New Scientist

This just makes a lot of sense…

Orbiting gas station could refuel lunar missions – space – 31 July 2009 – New Scientist: “FORGET huge, expensive rockets. A plan being examined by a US government panel would allow smaller, cheaper rockets to fly to the moon and beyond by stopping off at an ‘orbiting gas station’.

With conventional rockets, many tonnes of fuel are needed on such missions for each tonne of payload. Sending astronauts or the heftiest robotic probes to these distant destinations therefore requires huge launchers.”

IZOD and Lacoste: What’s the Difference?

mental_floss Blog » IZOD and Lacoste: What’s the Difference?: “As it turns out, Lacoste is a subbrand of IZOD. As Aristotle would put it: All Lacostes are IZODs, but not all IZODs are Lacostes. These days, both brands are owned by the garment giant Phillips-Van Heusen Corporation, so the difference between Lacoste IZODs and non-Lacoste IZODs is primarily marketing. But the difference between the men behind IZOD and Lacoste is vast indeed.”

7 essential skills for modern living

In the ‘old’ days it was how to maintain a car, change a plug, now things are ‘different’…. these are the modern essential skills!

  1. How to assemble flat pack IKEA furniture
  2. How to find the right plugs for each of the leads on a computer (this one id soon to be destined for old fogies like me, as everyone now has laptops btw)
  3. Ability to navigate and find somewhere solely via blackberry GPS and Google maps
  4. Know the difference between a mp3 and mp4 player
  5. listen to music, IM,watch tv and do work at the same time
  6. Order a low fat 55deg, grande mocha latte and know what it is
  7. Be able to skip lunch (as you have probably ordered the above)

Second Thoughts on Fluoride: Scientific American

Second Thoughts on Fluoride: Scientific American: “Long before the passionate debates over cigarettes, DDT, asbestos or the ozone hole, most Americans had heard of only one environmental health controversy: fluoridation. Starting in the 1950s, hundreds of communities across the U.S. became embroiled in heated battles over whether fluorides—ionic compounds containing the element fluorine—should be added to their water systems. On one side was a broad coalition of scientists from government and industry who argued that adding fluoride to drinking water would protect teeth against decay; on the other side were activists who contended that the risks of fluoridation were inadequately studied and that the practice amounted to compulsory medication and thus was a violation of civil liberties.

The advocates of fluoride eventually carried the day, in part by ridiculing opponents such as the right-wing John Birch Society, which called fluoridation a communist plot to poison America. Today almost 60 percent of the U.S. population drinks fluoridated water, including residents of 46 of the nation’s 50 largest cities. Outside the U.S., fluoridation has spread to Canada, the U.K., Australia, New Zealand and a few other countries. Critics of the practice have generally been dismissed as gadflies or zealots by mainstream researchers and public health agencies in those countries as well as the U.S. (In other nations, however, water fluoridation is rare and controversial.) The U.S. Centers for Disease Control and Prevention even lists water fluoridation as one of the 10 greatest health achievements of the 20th century, alongside vaccines and family planning.

Now, though, scientific attitudes toward fluo­ri­da­tion may be starting to shift in the country where the practice began. After spending more than two years reviewing and debating hundreds of studies, a committee of the National Research Council (NRC) released a report in 2006 that gave a tinge of legitimacy to some longtime assertions made by antifluoridation campaigners. The report concluded that the Environmental Protection Agency’s current limit for fluoride in drinking water—four milligrams per liter (mg/L)—should be lowered because of health risks to both children and adults. In children, consistent exposure to fluoride at that level can discolor and disfigure emerging permanent teeth—a condition called dental fluorosis. In adults, the same fluoride level appears to increase the risk of bone fracture and, possibly, of moderate skeletal fluorosis, a painful stiffening of the joints. Most fluoridated water contains much less fluoride than the EPA limit, but the situation is worrisome because there is so much uncertainty over how much additional fluoride we ingest from food, beverages and dental products. What is more, the NRC panel noted that fluoride may also trigger more serious health problems, including bone cancer and damage to the brain and thyroid gland. Although these effects are still unproved, the panel argued that they deserve further study.

The largest long-running investigation of the effects of fluoride is the Iowa Fluoride Study, directed by Steven M. Levy of the University of Iowa College of Dentistry. For the past 16 years Levy’s research team has closely tracked about 700 Iowa children to try to tease out subtle effects of fluoridation that may have been overlooked by previous studies. At the same time, Levy is also leading one of the most extensive efforts ever to measure fluoride concentrations in thousands of products—including foods, drinks and toothpastes—to develop credible estimates of typical fluoride intake.

It is a maddeningly complex area of research because diets, toothbrushing habits and water fluoridation levels vary so much and also because genetic, environmental and even cultural factors appear to leave some people much more susceptible to the effects of fluoride—both positive and negative—than others. Despite all the uncertainties, however, Levy and some other fluoride researchers have come around to the view that some children, especially very young ones, are probably getting more fluoride than they should. Most of those scientists, including Levy, still support water fluoridation as a proved method of controlling tooth decay, especially in populations where oral hygiene is poor. But the researchers also believe that in communities with good dental care the case for fluoridation is not as strong as it used to be. “Instead of just pushing for more fluoride, we need to find the right balance,” Levy says.

The Advent of Fluoride
Framed toothpaste advertisements from more than half a century ago hang on the walls of Levy’s conference room. One touting Pebeco Toothpaste reads: “Do you want your teeth to ache and get ugly?” Another asserts that “Colgate Chlorophyll Toothpaste Destroys Bad Breath.” They are artifacts of the prefluoride era, when tooth decay—called caries in the parlance of dentistry—was pervasive and toothpastes were marketed with questionable medical claims.

The introduction of fluoride changed all that. In 1945 Grand Rapids, Mich., became the first city to fluoridate its water supply. Ten years later Procter & Gamble introduced Crest, the first fluoridated toothpaste, which contained stannous fluoride (a compound with one atom of tin and two of fluorine). Colgate-Palmolive followed in 1967 by modifying its Colgate brand with what has become one of the dominant cavity-fighting ingredients in toothpastes: sodium monofluorophosphate. Instead of sticking with the fluoride salts found in toothpastes and favored by dentists in office treatments, most water suppliers eventually switched to the cheaper option of fluoridating with silicofluorides such as hexafluorosilicic acid, a by-product of a fertilizer manufacturing process in which phosphate ores are treated with sulfuric acid.

By the 1970s and 1980s America was awash in various forms of fluoride, and fluoridation had become the cornerstone of preventative dentistry in most English-speaking countries. Exactly why and how much caries incidence decreased during the same period is a matter of fierce debate, but the consensus among dental researchers is that the decline was steep and that fluoride deserved much of the credit.

That was the culture in which Levy got his start in public health dentistry in the mid-1980s. Colgate-Palmolive funded his early research, which had the effect of encouraging more fluoride use in dental offices. But as American dentists began to see fewer cavities and more fluorosis on the teeth of their young patients, Levy started to wonder whether children were getting too much of a good thing. “There was a transition in my own thinking from ‘more fluoride is definitely our goal’ to making sure we understand where the right balance is between caries and fluorosis.”

Fluoride’s role in causing one disease and deterring another is rooted in the fluorine ion’s powerful attraction to calcium-bearing tissues in the body. In fact, more than 99 percent of ingested fluoride that is not quickly excreted ends up in bones and teeth. Fluoride inhibits cavities through two separate mechanisms. First, fluoride that touches the enamel—the hard, white outer layer of the teeth—becomes embedded in the crystalline structures of hydroxylapatite, the main mineral component of teeth and bones. The fluorine ions replace some of the hydroxyl groups in the hydroxylapatite molecules of the enamel, and this substitution makes teeth slightly more resistant to the enamel-dissolving acid excreted by bacteria in the mouth as they consume food remnants. Second, the fluoride on the surface of teeth serves as a catalyst that enhances the deposition of calcium and phosphate, making it easier for the body to continually rebuild the enamel crystals that the bacteria are dissolving.

Fluoride has a very different effect, however, when large doses are ingested by young children whose permanent teeth are still developing and have not yet erupted. The key proteins in early tooth formation are called amelogenins, which regulate the formation of hydrox­ylapatite crystals. As a crystal matrix forms, the amelogenins break down and are removed from the maturing enamel. But when some children consume high doses of fluoride, which is absorbed through the digestive tract and delivered by the bloodstream to the developing teeth, the biochemical signaling goes awry and the proteins remain inside the budding tooth longer than usual, thereby creating gaps in the crystalline enamel structure. As a result, when a fluorosed tooth finally erupts it is often unevenly colored, with some portions whiter than others—a visual effect caused by light refracting off the porous enamel. In more severe cases, the surface of the tooth is pitted and the stains are brown. Nutrition and genetics can influence the risk of fluorosis, but the most important factor by far is the amount of fluoride ingested.

With grant money from the National Institute of Dental and Craniofacial Research, Levy set out to determine how much fluoride children consume and how it affects their teeth and bones. There is no universally accepted optimal level for daily intake of fluoride—that is, a level that maximizes protection against tooth decay while minimizing other risks—but the range most often cited by researchers is 0.05 to 0.07 milligram of fluoride per kilogram of body weight per day. In the early 1990s, when the children in Levy’s study were infants, he found that more than a third of them were ingesting enough fluoride—mostly via water-based infant formula, baby foods and juice drinks—to put them at a high risk of developing mild fluorosis in their permanent teeth. That fraction dropped only slightly as their diet changed during their toddler years—a critical period for enamel formation in preemergent teeth. Typical fluoride ingestion stayed high during the toddler years, in part because toothpaste replaced formula as a key source. Although both children and adults are supposed to spit out their toothpaste after brushing, Levy had found in an earlier study that toddlers on average actually swallowed more than half of their toothpaste.

By the time the Iowa children were nine years old and their permanent front teeth had emerged, it was obvious that the earlier exposures to fluoride had literally left their mark. The front teeth of children who had been in the high-intake group as infants and toddlers were more than twice as likely to show the telltale staining of fluorosis than the teeth of children who had ingested less fluoride when they were younger. And as their diet broadened, so did their sources of fluoride. Tests performed in Levy’s lab found, for example, that many kinds of juice drinks and soda pop contain enough fluo­ride (generally about 0.6 mg/L) so that drinking a little more than a liter a day would put a typical three-year-old at the optimal intake level, without counting any other daily sources.

Dozens of food items tested by Levy’s team contained even higher concentrations of fluoride: an average of 0.73 mg/L in cranberry-juice cocktail, 0.71 mg/L in ice pops, 0.99 mg/L in beef gravy and 2.10 mg/L in canned crabmeat, for example. In most cases, the fluoride came from water added during processing, although higher levels also got into grapes and raisins via pesticides, into processed chicken products via ground-up bone, and into tea leaves via absorption from soil and water.

Levy found that exposure to fluoridated drinking water was an even more important risk factor for fluorosis. Iowa children who lived in communities where the water was fluoridated were 50 percent more likely to have mild fluorosis on at least two of their eight permanent front teeth at nine years of age than children living in nonfluoridated areas of the state (there was a 33 percent prevalence in the former versus 22 percent in the latter). Similar results appeared in the NRC report, which found that infants and toddlers in fluoridated communities ingest about twice as much fluoride as they should. Furthermore, the committee noted that adults who drink above-average amounts of water, including athletes and laborers, are also exceeding the optimal level for fluoride intake.

But enamel fluorosis, except in the severest cases, has no health impact beyond lowered self-esteem: the tooth marks are unattractive and do not go away (although there are masking treatments). The much more important question is whether fluoride’s effects extend beyond altering the biochemistry of tooth enamel formation. Says longtime fluoride researcher Pamela DenBesten of the University of California, San Francisco, School of Dentistry: “We certainly can see that fluoride impacts the way proteins interact with mineralized tissue, so what effect is it having elsewhere at the cellular level? Fluoride is very powerful, and it needs to be treated respectfully.”

Fluoride and Bone
Bone is an obvious place to look for fluoride’s fingerprints because so much fluoride is stored there. What is more, studies of patients with osteoporosis—a bone disease that increases the risk of fractures—have shown that high doses of fluoride can stimulate the proliferation of bone-building osteoblast cells, even in elderly patients. The exact mechanism is still unknown, but fluoride appears to achieve this by increasing the concentrations of tyrosine-phosphorylated proteins, which are involved in biochemical signaling to osteoblasts. As with tooth enamel, however, fluoride not only stimulates bone mineralization, it also appears to alter the crystalline structure of bone—and in this case, the effects are not merely aesthetic. Although fluoride may increase bone volume, the strength of the bone apparently declines. Epidemiological studies and tests on lab animals suggest that high fluoride exposure increases the risk of bone fracture, especially in vulnerable populations such as the elderly and diabetics. Although those studies are still somewhat controversial, nine of the 12 members of the NRC panel concluded that a lifetime of exposure to drinking water fluoridated at 4 mg/L or higher does indeed raise the risk of fracture. The committee noted that lower fluoridation levels may also increase the risk, but the evidence is murkier.

As the Iowa children in his study enter adolescence, Levy hopes that analyses of the strength of their spine, hips and overall skeleton will point to possible connections between fluoride intake and bone health. He presented some preliminary data in 2007, finding little difference in the mineral content of the bones of 11-year-olds based on how much fluoride they had ingested as young children. As they go through adolescence, however, Levy thinks that trends may emerge.

The even bigger question looming over the fluoride debate is whether these known cellular effects in bones and teeth are clues that fluoride is affecting other organs and triggering other diseases besides fluorosis. The biggest current debate is over osteosarcoma—the most common form of bone cancer and the sixth most prevalent cancer in children. Because fluoride stimulates the production of osteoblasts, several researchers have suggested that it might induce malignant tumors in the expanding cell population. A 1990 study conducted by the U.S. government’s National Toxicology Program found a positive dose-response relation for osteosarcoma incidence in male rats exposed to different amounts of fluoride in drinking water (all those amounts, as is typical for animal studies, were far above the actual exposures found in fluoridated communities). But other animal studies as well as most epidemiological studies in human populations have been ambiguous at best.

The latest dustup over fluoride and osteosarcoma was instigated by a young researcher named Elise B. Bassin of the Harvard School of Dental Medicine. Bassin collected information about fluoride exposures among 103 osteosarcoma patients and 215 matched control subjects and concluded that fluoride is a risk factor for the cancer among boys (the results were ambiguous for girls). Bassin’s report appeared in 2006 in the journal Cancer Causes and Control; in the same issue, however, her dissertation adviser at Harvard, Chester Douglass, wrote a commentary warning readers to be “especially cautious” in interpreting her findings because, he said, better data, still unpublished, contradict them. Antifluoridationists and some environmental groups quickly rushed to Bassin’s defense, demanding that Harvard investigate Douglass, professor and chair of epidemiology at the dental school, for allegedly misrepresenting Bassin’s work and for having a conflict of interest because he is editor in chief of a newsletter for dentists funded by Colgate. The university’s investigation of Doug­lass, completed in 2006, concluded that there was no misconduct or conflict of interest.

Clashes over the possible neurological effects of fluoride have been just as intense. Phyllis Mullenix, then at the Forsyth Institute in Boston, set off a firestorm in the early 1990s when she reported that experiments on lab rats showed that sodium fluoride can accumulate in brain tissue and affect animal behavior. Prenatal exposures, she reported, correlated with hyperactivity in young rats, especially males, whereas exposures after birth had the opposite effect, turning female rats into what Mullenix later described as “couch potatoes.” Although her research was eventually published in Neurotoxicology and Teratology, it was attacked by other scientists who said that her methodology was flawed and that she had used unrealistically high dosages. Since then, however, a series of epidemiological studies in China have associated high fluoride exposures with lower IQ, and research has also suggested a possible mechanism: the formation of aluminum fluoride complexes—small inorganic molecules that mimic the structure of phosphates and thus influence enzyme activity in the brain. There is also some evidence that the silicofluorides used in water fluoridation may enhance the uptake of lead into the brain.

The endocrine system is yet another area where some evidence exists that fluoride can have an impact. The NRC committee concluded that fluoride can subtly alter endocrine function, especially in the thyroid—the gland that produces hormones regulating growth and metabolism. Although researchers do not know how fluoride consumption can influence the thyroid, the effects appear to be strongly influenced by diet and genetics. Says John Doull, professor emeritus of pharmacology and toxicology at the University of Kansas Medical Center, who chaired the NRC committee: “The thyroid changes do worry me. There are some things there that need to be explored.”

The Controversy Continues
The release of the NRC report has not triggered a public stampede against fluoridation, nor has it prompted the EPA to quickly lower its fluoride limit of 4 mg/L (the agency says it is still studying the issue). Water suppliers who add fluoride typically keep levels between 0.7 to 1.2 mg/L, far below the EPA limit. About 200,000 Americans—and several million people in China, India, the Middle East, Africa and Southeast Asia—drink concentrations higher than the limit, but their excess fluoride comes from naturally occurring runoff from fluoride-containing rocks and soils near water sources.

The report is, however, prompting some researchers to wonder whether even 1 mg/L is too much in drinking water, in light of the growing recognition that food, beverages and dental products are also major sources of fluoride, especially for young children. The NRC committee did not formally address the question, but its analyses suggest that lower water fluoridation levels may pose risks, too. “What the committee found is that we’ve gone with the status quo regarding fluoride for many years—for too long, really—and now we need to take a fresh look,” Doull says. “In the scientific community, people tend to think this is settled. I mean, when the U.S. surgeon general comes out and says this is one of the 10 greatest achievements of the 20th century, that’s a hard hurdle to get over. But when we looked at the studies that have been done, we found that many of these questions are unsettled and we have much less information than we should, considering how long this [fluoridation] has been going on. I think that’s why fluoridation is still being challenged so many years after it began. In the face of ignorance, controversy is rampant.”

Some longtime fluoride researchers, however, remain unimpressed by the evidence of effects beyond teeth and bones, and they continue to push for an expansion of water fluoridation in the U.S. and elsewhere. Their view remains the official position of the American Dental Association and the U.S. Public Health Service. “We feel there are enough communities out there with high caries rates to justify additional fluoridation,” says Jayanth V. Kumar, director of oral health surveillance and research at the New York State Department of Health and a member of the NRC panel who dissented from some of its findings. He acknowledges, however, that the argument for water fluoridation is not as strong in affluent areas with good nutrition and dental care. “Today it depends on what the caries level is in the community. If the disease is low, the return on investment [for fluoridation] may not be all that great.”

Opponents of fluoridation, meanwhile, have been emboldened by the NRC report. “What the committee did was very, very important, because it’s the first time a truly balanced panel has looked at this and raised important questions,” says Paul Connett, a chemistry professor at St. Lawrence University and the executive director of the Fluoride Action Network, one of the most active antifluoridation groups worldwide. “I absolutely believe it’s a scientific turning point because now everything’s on the table. Fluoride is the most consumed drug in the U.S., and it’s time we talked about it.””

BBC NEWS | Europe | Swedes miss Capri after GPS gaffe

BBC NEWS | Europe | Swedes miss Capri after GPS gaffe: “A Swedish couple in search of the isle of Capri drove to Carpi, an industrial town in northern Italy, because they misspelt the name in their car’s GPS.

Italian officials say the couple asked at Carpi’s tourist office where they could find Capri’s famous Blue Grotto.

The car’s sat nav system had sent them 650km (400 miles) off course to Carpi.

‘Capri is an island. They did not even wonder why they didn’t cross any bridge or take any boat,’ said a bemused tourism official in Carpi.

Once they realised their mistake, the couple got back in their car and headed south, the official added.”

Is the US Economy Close to Hitting Bottom? – Frank Shostak – Mises Institute

Is the US Economy Close to Hitting Bottom? – Frank Shostak – Mises Institute: “Most experts and commentators are of the view that the worst of the US recession may be over by year’s end. My own prediction is for an illusory recovery of government-constructed economic indicators, but nothing more than that.

Most experts are of the view that the worst of the US recession may be over by year’s end. Common opinion holds that the key reason for the expected turnaround is the positive effect that the policies of the government and Fed have on various economic indicators. The pace of monetary pumping by the US central bank jumped from 4% in September 2007 to 152% by December 2008. With respect to fiscal stimulus, aggressive government spending has resulted in a record deficit of over one trillion dollars in the first nine months of fiscal year 2009. Careful examination shows that, rather than protecting the economy, it is loose monetary policies that are the key source of boom-bust economic cycles. Loose Fed and government fiscal policies have only weakened the wealth generators’ ability to grow the economy. Aggressive policies have inflicted severe damage to the sources of funding that support real economic growth. Hence, we are doubtful that the US economy is on the verge of a solid economic recovery. On account of massive monetary pumping, the growth in momentum of various key economic data is likely to strengthen in the months ahead. We maintain this may prompt Fed policy makers to consider curtailing the pace of monetary pumping, and we suggest that this will set in motion a new economic bust.”

The calorie delusion: Why food labels are wrong – health – 15 July 2009 – New Scientist

The calorie delusion: Why food labels are wrong – health – 15 July 2009 – New Scientist: “STANDING in line at the coffee shop you feel a little peckish. So what will you choose to keep you going until lunchtime? Will it be that scrumptious-looking chocolate brownie or perhaps a small, nut-based muesli bar. You check the labels: the brownie contains around 250 kilocalories (kcal), while the muesli bar contains more than 300. Surprised at the higher calorie count of what looks like the healthy option, you go for the brownie.”

Spy probe images Apollo landing sites – space – 18 July 2009 – New Scientist

Spy probe images Apollo landing sites – space – 18 July 2009 – New Scientist: “Those who suspect the Apollo lunar landings were faked may have trouble arguing with new orbital images of hardware and tracks left in the lunar dust by Apollo astronauts in the 1960s and ’70s.

The images were taken by NASA’s Lunar Reconnaissance Orbiter (LRO) less than a month after it launched. ‘I believe this is the first time Apollo hardware has been imaged by anyone in the post-Apollo era,’ Richard Vondrak, LRO project scientist at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, told reporters on Friday.”

Aftershocks at G-8 Summit Site in Italy Raise Concerns – washingtonpost.com

Aftershocks at G-8 Summit Site in Italy Raise Concerns – washingtonpost.com: “Italian authorities are betting that a side benefit of holding the summit in the mountains is that the remote location will make it more difficult for anti-globalization demonstrators to disrupt the G-8 summit. Road access to L’Aquila has been sharply curtailed this week, with police manning checkpoints and highway overpasses all the way to Rome, 60 miles away.”